RMC-3943

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

RMC-3943 

RMC-3943 是一种变构性 SHP2 抑制剂 (抑制全长的 IC50 值为 2.19 nM)。

RMC-3943

RMC-3943 Chemical Structure

CAS No. : 1801764-60-2

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生物活性

RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM)[1].

体外研究
(In Vitro)

RMC-3943 inhibits pERK in PC9 cells, with an IC50 of 35.5 nM[1].
RMC-3943 (0-10 μM) produces a concentration-dependent inhibition of proliferation of SK-MEL-113 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line: SK-MEL-113 cells[1].
Concentration: 0-10 μM.
Incubation Time: 7 days.
Result: Inhibited cell proliferation.

分子量

425.38

Formula

C18H22Cl2N6S

CAS 号

1801764-60-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Efficacy of SHP2 phosphatase inhibition in cancers with nucleotide-cycling oncogenic RAS, RAS-GTP dependent oncogenic BRAF and NF1 loss. BioRxiv. 2021 Aug.

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