AI-10-47

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AI-10-47  纯度: 99.74%

AI-10-47 是 CBFβ-RUNX 结合的小分子抑制剂,其 IC50 值为 3.2 μM。

AI-10-47

AI-10-47 Chemical Structure

CAS No. : 1256094-31-1

规格 价格 是否有货 数量
5 mg ¥2000 In-stock
10 mg ¥3500 In-stock
25 mg ¥6500 In-stock
50 mg ¥9500 In-stock
100 mg ¥13500 In-stock
200 mg   询价  
500 mg   询价  

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AI-10-47 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library
  • Targeted Diversity Library

生物活性

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM[1].

体外研究
(In Vitro)

AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding[1].
AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: 4 × 106 SEM cells.
Concentration: 10 μM.
Incubation Time: 6 h.
Result: Weakly reduced CBFβ binding to RUNX1 in cells (may due to its poor solubility).

分子量

279.22

Formula

C13H8F3N3O

CAS 号

1256094-31-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (358.14 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5814 mL 17.9070 mL 35.8141 mL
5 mM 0.7163 mL 3.5814 mL 7.1628 mL
10 mM 0.3581 mL 1.7907 mL 3.5814 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Anuradha Illendula, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-131.

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