DBCO-PEG4-GGFG-DX8951

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

DBCO-PEG4-GGFG-DX8951 

DBCO-PEG4-GGFG-DX8951 是抗体-药物偶联物的一部分，由 DNA 拓扑异构酶 I 抑制剂 DX8951 和不可降解的 ADC linker DBCO-PEG4-GGFG 连接而成。

DBCO-PEG4-GGFG-DX8951

DBCO-PEG4-GGFG-DX8951 Chemical Structure

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生物活性

DBCO-PEG4-GGFG-DX8951 is a drug-linker conjugate for ADC with potent antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the non-cleavable ADC linker DBCO-PEG4-GGFG[1].

IC50 & Target

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linke[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1375.45

Formula

C72H79FN10O17
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anish Thomas, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17(6):e254-e262.

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