SK33

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SK33 

SK33，肌醇类似物，是一种有效的组织选择性抗雄激素药物。SK33 降低雄激素受体 (AR) 的转录活性。

SK33

SK33 Chemical Structure

CAS No. : 1928724-23-5

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生物活性

SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1].

体外研究
(In Vitro)

In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: LNCaP/BicR cells
Concentration: 0.1-100 μM
Incubation Time: 96 hours
Result: Results in a dose-dependent response and an inhibition of cell growth.

体内研究
(In Vivo)

SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ARE-Luc mice[1]
Dosage: 50 mg/kg
Administration: Subcutaneously; 24 hours
Result: Inhibited AR transcriptional activity.

分子量

500.31

Formula

C20H13F9N2O3
CAS 号

1928724-23-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dart DA, et al. Novel Trifluoromethylated Enobosarm Analogues with Potent Antiandrogenic Activity In Vitro and Tissue Selectivity In Vivo.Mol Cancer Ther. 2018 Sep;17(9):1846-1858.

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