MTH1-IN-2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

MTH1-IN-2 

MTH1-IN-2 是一种 MutT 同源酶1 (MTH1) 抑制剂,详细信息请参考专利 WO2016135138A1 的化合物 (6)。MTH1-IN-2 具有抗肿瘤活性,有潜力用于癌症方面的研究。

MTH1-IN-2

MTH1-IN-2 Chemical Structure

CAS No. : 901044-91-5

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生物活性

MTH1-IN-2 is a MutT homolog 1 (MTH1) inhibitor extracted from patent WO2016135138A1, Compound (6), MTH1-IN-2 can be used for the research of cancer. Anti-tumor activity[1].

IC50 & Target

MTH1[1]

体外研究
(In Vitro)

The enzyme human MTH1 is a 2-hydroxy-dATP diphosphatase. MTH1 specifically assists RAS-induced tumors in preventing tumor- suppressive effects such as senescence whilst enabling maintenance and progression of the tumor. MTH1 inhibition helps impairing tumor growth by abrogating mitogenic signaling, epithelial-mesenchymal transition (EMT), a hallmark of progressing and aggressive tumors, anoikis inhibition and PI3K/Akt-mediated pro-survival signaling. MTH1 inhibitors induce oxidative DNA lesions[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

469.55

Formula

C24H27N3O5S

CAS 号

901044-91-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kilian Huber. Oxoquinoline derivatives as mth1 inhibitors for the therapy of cancer. WO2016135138A1.

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