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BPH-1358 free base (Synonyms: NSC50460 free base)
BPH-1358 free base (NSC50460 free base) 是一种有效的人 FPPS 和 UPPS 抑制剂，IC50 值分别为 1.8 μM 和 110 nM，在体外对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。
BPH-1358 free base Chemical Structure
CAS No. : 801985-13-7
| 规格 | 是否有货 | ||
|---|---|---|---|
| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
BPH-1358 free base (NSC50460 free base) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2]. |
IC50 & Target |
IC50: 1.8 μM (human bisphosphonate farnesyl diphosphate synthase)[1]; 100 nM (undecaprenyl diphosphate synthase)[2] |
|---|---|
| 体外研究 (In Vitro) |
BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC50 of 110 nM. BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 (In Vivo) |
BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain)[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
528.60 |
| Formula |
C32H28N6O2 |
| CAS 号 |
801985-13-7 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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