EMI1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EMI1 

EMI1 是 EGFR 三重突变体 EGFR ex19del/T790M/C797S 和 EGFR L858R/T790M/C797S 的有效抑制剂。EMI1 可用于与 EGFR 突变相关的耐药型非小细胞肺癌 (NSCLC) 的研究。

EMI1

EMI1 Chemical Structure

CAS No. : 35773-42-3

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生物活性

EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].

IC50 & Target[1]

EGFRdel19 T790M C797S

 

EGFRL858R/T790M/C797S

 

体外研究
(In Vitro)

EMI1 inhibits PC9 EGFR ex19del/T790M/C797S organoid growth with the EC50 of 131 nM[1].
EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1[1].
EMI1 (1 nM-100μM) strongly inhibits the viability and increase the caspase 3/7 activity of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PC9 EGFR ex19del/T790M/C797S and HBE bronchial epithelial lung EGFR-WT control cells.
Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 72 hours
Result: Strongly inhibited the viability.

分子量

334.37

Formula

C20H18N2O3
CAS 号

35773-42-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Punit Saraon, et al. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat Chem Biol. 2020 May;16(5):577-586.

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