MAC glucuronide α-hydroxy lactone-linked SN-38

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MAC glucuronide α-hydroxy lactone-linked SN-38 

MAC glucuronide α-hydroxy lactone-linked SN-38 是一种稳定的内酯化合物，由 ADC 毒物 SN-38 (Topoisomerase I 抑制剂) 和 MAC glucuronide α-hydroxy lactone 组成。MAC glucuronide α-hydroxy lactone-linked SN-38 对 L540cy 细胞和 Ramos 细胞具有细胞毒性，IC50 分别为 99 和 105 ng/mL。

MAC glucuronide α-hydroxy lactone-linked SN-38

MAC glucuronide α-hydroxy lactone-linked SN-38 Chemical Structure

CAS No. : 2246380-70-9

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生物活性

MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].

IC50 & Target

Camptothecins

 

分子量

1091.06

Formula

C50H54N6O20S
CAS 号

2246380-70-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072.

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