R-BC154 acetate

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

R-BC154 acetate 

R-BC154 acetate 是一种选择性的荧光 α9β1 整合素拮抗剂。R-BC154 acetate 可以作为高亲和力、活化依赖的整合素探针,可用于研究促细胞生长因子 α9β1 和 α4β1 的结合活性。

R-BC154 acetate

R-BC154 acetate Chemical Structure

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生物活性

R-BC154 acetate is a selective fluorescent α9β1 integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity[1].

IC50 & Target[1]

α9β1

 

体外研究
(In Vitro)

R-BC154 acetate has 3 times greater affinities for α9β1 (Ki=12.7 nM) relative to α4β1 (Ki=38.0 nM) under Ca2+/Mg2+ conditions in human glioblastoma LN18 cell lines[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

R-BC154 acetate (10 mg/kg; i.v.) acts as an in vivo probe for bone marrow haemopoietic stem cells in mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6 mice (6-8 weeks old)[1]
Dosage: 10 mg/kg
Administration: Intravenous injection
Result: Was capable of binding haemopoietic progenitor cells and HSC within mice bone marrow in vivo.

分子量

1184.36

Formula

C56H65N9O14S3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org Biomol Chem. 2014 Feb 14;12(6):965-78.

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