CID 5951923

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CID 5951923 

CID 5951923是一种有效的 Krüppel-like factor 5 (KLF5) 抑制剂，IC50 值为 603 nM，CID 5951923 可在体外抑制癌细胞的增殖。

CID 5951923

CID 5951923 Chemical Structure

CAS No. : 749872-43-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CID 5951923 is a potent inhibitor of Krüppel-like factor 5 (KLF5), with an IC50 of 603 nM. CID 5951923 can inhibit proliferation of cancer cells in vitro[1].

IC50 & Target

IC50: 603 nM (KLF5)[1]
体外研究
(In Vitro)

CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner[1].
CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY1068, and downregulated EGR1[1].
CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: DLD-1 and IEC-6 cells
Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 48 h
Result: Inhibited proliferation of DLD-1 cells with an IC50 of 1.6 μM.

分子量

382.39

Formula

C16H18N2O7S
CAS 号

749872-43-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bialkowska AB, et, al. Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol Cancer Ther. 2011 Nov; 10(11): 2043-51.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务