Carbidopa monohydrate(Synonyms: (S)-(-)-Carbidopa monohydrate)

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Carbidopa monohydrate (Synonyms: (S)-(-)-Carbidopa monohydrate)

Carbidopa ((S)-(-)-Carbidopa) monohydrate 是一种外周型脱羧酶 (decarboxylase) 抑制剂，可用于帕金森病的研究。Carbidopa monohydrate 是一种选择性芳香烃受体 (AhR) 调节剂。Carbidopa monohydrate 抑制胰腺癌细胞和肿瘤生长。

Carbidopa monohydrate(Synonyms: (S)-(-)-Carbidopa monohydrate)

Carbidopa monohydrate Chemical Structure

CAS No. : 38821-49-7

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Carbidopa monohydrate 的其他形式现货产品:

Carbidopa

生物活性

Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson’s disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2].

体外研究
(In Vitro)

Carbidopa ((S)-(-)-Carbidopa) monohydrate exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191[1].
Carbidopa, a aromatic-L-amino acid decarboxylase inhibitor, is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Carbidopa is lethal (IC50=29 μM)[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Carbidopa monohydrate also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

244.24

Formula

C10H16N2O5
CAS 号

38821-49-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Safe S. Carbidopa: a selective Ah receptor modulator (SAhRM). Biochem J. 2017;474(22):3763-3765. Published 2017 Nov 6.

    [2]. Fermaglich J. Treatment of Parkinson’s disease with carbidopa, a peripheral decarboxylase inhibitor, and levodopa. Med Ann Dist Columbia. 1974;43(12):587-591.

    [3]. Gilbert JA, et al. The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Clin Cancer Res. 2000;6(11):4365-4372.

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