Rachelmycin(Synonyms: CC-1065; NSC 298223)

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Rachelmycin (Synonyms: CC-1065; NSC 298223)

Rachelmycin (CC-1065; NSC 298223) 是一种从 Streptomyces zelensis 中分离得到有效的天然抗生素 (antibiotic)。Rachelmycin 在 B 型 DNA 的小沟中非共价和共价结合 (N-3 腺嘌呤加合物)。Rachelmycin 具有极强的抗肿瘤活性。

Rachelmycin(Synonyms: CC-1065;  NSC 298223)

Rachelmycin Chemical Structure

CAS No. : 69866-21-3

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生物活性

Rachelmycin (CC-1065; NSC 298223) is a potent naturally antibiotic isolated from Streptomyces zelensis. Rachelmycin binds non-covalently and covalently (N-3 adenine adduct) in the minor groove of B-form DNA. Rachelmycin has exceptionally potent antitumor activity[1].

体内研究
(In Vivo)

The smallest dose at which delayed death occurs is less for Rachelmycin (CC-1065; NSC 298223; 12.5 mg/kg) in experiments with non-tumored BDF1 mice[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

703.70

Formula

C37H33N7O8

CAS 号

69866-21-3

中文名称

拉奇霉素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. W C Krueger, et al. Calf Thymus DNA binding/bonding Properties of CC-1065 and Analogs as Related to Their Biological Activities and Toxicities. Chem Biol Interact. 1992 Mar;82(1):31-46.

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