Calcimycin hemimagnesium(Synonyms: A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium)

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Calcimycin hemimagnesium (Synonyms: A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium)

Calcimycin (A-23187) hemimagnesium 是一种抗生素和独特的二价阳离子离子载体 (divalent cation ionophore)，如钙离子和镁离子。Calcimycin hemimagnesium 通过增加细胞内钙浓度诱导 Ca2+ 依赖性细胞死亡。Calcimycin hemimagnesium 抑制革兰氏阳性细菌和一些真菌的生长，还抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化 (OXPHOS)，诱导细胞凋亡 (apoptosis)。

Calcimycin hemimagnesium(Synonyms: A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium)

Calcimycin hemimagnesium Chemical Structure

CAS No. : 72124-77-7

规格 价格 是否有货
1 mg ￥2600 询问价格 & 货期
5 mg ￥7200 询问价格 & 货期

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Calcimycin hemimagnesium 的其他形式现货产品:

Calcimycin

生物活性

Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4].

体外研究
(In Vitro)

Calcimycin (A-23187) hemimagnesium mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (ICR, 25-30 g)[5]
Dosage: 2.5 or 7.5 nM
Administration: Intrapleurally
Result: Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.

Clinical Trial

分子量

1069.53

Formula

C58H72MgN6O12
CAS 号

72124-77-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82.

    [2]. Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94.

    [3]. Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90.

    [4]. Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200.

    [5]. Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):90-5.

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