上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
TNP-351
TNP-351 是一种抗叶酸剂。TNP-351 是一种二氢叶酸还原酶 (DHFR) 抑制剂,在体内外对白血病和实体瘤细胞均具有有效的抗肿瘤活性。
TNP-351 Chemical Structure
CAS No. : 125991-51-7
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生物活性 |
TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1]. |
IC50 & Target |
Antifolate, DHFR[1] |
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体外研究 (In Vitro) |
TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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分子量 |
440.45 |
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Formula |
C21H24N6O5 |
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CAS 号 |
125991-51-7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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