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N-Succinimidyl 3-(Bromoacetamido)propionate (Synonyms: 3-(2-Bromoacetamido)propanoic acid NHS ester)
N-Succinimidyl 3-(Bromoacetamido)propionate 是一种 PROTAC linker，属于 PEG 类。可用于合成PROTAC分子。N-Succinimidyl 3-(Bromoacetamido)propionate 也是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)。
N-Succinimidyl 3-(Bromoacetamido)propionate Chemical Structure
CAS No. : 57159-62-3
| 规格 | 是否有货 | ||
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| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
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| IC50 & Target |
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| 体外研究 (In Vitro) |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
307.10 |
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| Formula |
C9H11BrN2O5 |
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| CAS 号 |
57159-62-3 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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