Fmoc-NH-PEG4-CH2COOH

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Fmoc-NH-PEG4-CH2COOH 

Fmoc-NH-PEG4-CH2COOH 是一种可降解的 ADC linker，用于抗体药物偶联物 (ADC) 合成。Fmoc-NH-PEG4-CH2COOH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

Fmoc-NH-PEG4-CH2COOH

Fmoc-NH-PEG4-CH2COOH Chemical Structure

CAS No. : 437655-95-3

规格 价格 是否有货 数量
100 mg ￥1200 In-stock
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生物活性

Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Cleavable

 

Alkyl/ether

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

473.52

Formula

C25H31NO8
CAS 号

437655-95-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Maggie Lu, et al. Linker-wirkstoff und antikörper-wirkstoff-konjugat (adc) damit. EP3335734A1.

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