Boc-NH-PEG1-CH2CH2COOH

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Boc-NH-PEG1-CH2CH2COOH 

Boc-NH-PEG1-CH2CH2COOH 是一种可降解 (cleavable) 的含 1 个单元 PEG 的 ADC linker，同时也是 PROTAC linker，属于 PEG 和 Alkyl/ether 类，可用于合成抗体偶联药物 (ADC) 和 PROTAC。

Boc-NH-PEG1-CH2CH2COOH

Boc-NH-PEG1-CH2CH2COOH Chemical Structure

CAS No. : 1260092-44-1

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生物活性

Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG– and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs[1][2].

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

233.26

Formula

C10H19NO5
CAS 号

1260092-44-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Alex Cortez, et al.Antibody conjugates comprising toll-like receptor agonist and combination therapies. WO2018198091A1.

    [2]. Darren H. Wakefield, et al. Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery. US20130121954A1.

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