Periplocymarin(Synonyms: 杠柳次苷)

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Periplocymarin (Synonyms: 杠柳次苷)

Periplocymarin 是从 Periploca sepiumPeriploca graeca 中分离得到的一种强心苷,是一种潜在的抗癌化合物。

Periplocymarin(Synonyms: 杠柳次苷)

Periplocymarin Chemical Structure

CAS No. : 32476-67-8

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Periplocymarin 相关产品

相关化合物库:

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生物活性

Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound[1][2].

体外研究
(In Vitro)

Periplocymarin inhibits proliferation of PC3, U937, HCT-8, Bel-7402, BGC823, A549, and A2780 cell lines in vitro with IC50 values of 0.02-0.29 µM[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

534.68

Formula

C30H46O8

CAS 号

32476-67-8

中文名称

杠柳次苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Martey ON, et al. Periplocymarin is a potential natural compound for drug development: highly permeable with absence of P-glycoprotein efflux and cytochrome P450 inhibitions. Biopharm Drug Dispos. 2014 May;35(4):195-206.

    [2]. Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfidebond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy. Drug Deliv. 2017 Nov;24(1):1170-1178.

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