Yatein(Synonyms: 亚太因)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Yatein (Synonyms: 亚太因)

Yatein 是从 A. chilensis 中提取的木质素，具有抗增殖活性。Yatein 能通过中断立早基因的表达，抑制单纯疱疹病毒 1 型 (HSV-1) 的复制。

Yatein(Synonyms: 亚太因)

Yatein Chemical Structure

CAS No. : 40456-50-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Yatein is a lignan isolated from A. chilensis, with antiproliferative activity[1]. Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression[2].

IC50 & Target

HSV-1[2]
体外研究
(In Vitro)

Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells[3].
Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells[3].
Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[3]

Cell Line: A549 cells, CL1-5 cells
Concentration: 1.25 μM , 2.5 μM , 5 μM
Incubation Time: 24 hours
Result: Induced cell-cycle arrest at G2/M phase in both cell lines.

Western Blot Analysis[3]

Cell Line: A549 cells, CL1-5 cells
Concentration: 5 μM
Incubation Time: 6 hours, 12 hours
Result: Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation.

体内研究
(In Vivo)

Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NOD/SCID mice (6-8 weeks), with A549 cells xenograft[3]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection, five times per week, for 42 days
Result: Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation.

分子量

400.42

Formula

C22H24O7
CAS 号

40456-50-6
中文名称

亚太因
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Donoso-Fierro C, et al. Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. Pharm Biol. 2015 Mar;53(3):378-85.

    [2]. Kuo YC, et al. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 2006 Jul;70(3):112-20.

    [3]. Shang-Tse Ho, et al. Molecular Mechanisms Underlying Yatein-Induced Cell-Cycle Arrest and Microtubule Destabilization in Human Lung Adenocarcinoma Cells. Cancers (Basel). 2019 Sep; 11(9): 1384.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务