Peptide C105Y

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Peptide C105Y 

Peptide C105Y,基于 α1-抗胰蛋白酶 359-374 残基氨基酸序列合成的细胞穿透性肽,能增强 DNA 纳米粒的基因表达。

Peptide C105Y

Peptide C105Y Chemical Structure

CAS No. : 247572-63-0

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生物活性

Peptide C105Y, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles[1].

体外研究
(In Vitro)

When human hepatoma cells (HuH7) were incubated with fluorescently labeled C105Y for as little as 3 min, C105Y displays nuclear and cytoplasmic staining with enrichment of fluorescent signal in the nucleus and nucleolus. C105Y peptide is routed to the nucleolus very rapidly in an energy-dependent fashion, whereas membrane translocation and nuclear localization are energy-independent. When tested the involvement of known endocytosis pathways in uptake and trafficking of this peptide, C105Y peptide is internalized by a clathrin- and caveolin-independent pathway, although lipid raft-mediated endocytosis may play a role in peptide intracellular trafficking[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1994.40

Formula

C97H148N20O23S

CAS 号

247572-63-0

Sequence

Cys-Ser-Ile-Pro-Pro-Glu-Val-Lys-Phe-Asn-Lys-Pro-Phe-Val-Tyr-Leu-Ile

Sequence Shortening

CSIPPEVKFNKPFVYLI

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Rhee M, et al. Mechanism of uptake of C105Y, a novel cell-penetrating peptide. J Biol Chem. 2006 Jan 13;281(2):1233-40.

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