Phenoxybenzamine-d5 hydrochloride(Synonyms: 盐酸酚苄明 d5 (盐酸盐))

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Phenoxybenzamine-d5 hydrochloride (Synonyms: 盐酸酚苄明 d5 (盐酸盐))

Phenoxybenzamine-d5 hydrochloride 是 Phenoxybenzamine hydrochloride 的氘代物。Phenoxybenzamine hydrochloride 是具有选择行的 α-adrenoceptor 和 calmodulin 的抑制剂，是一种常用的抗高血压药。

Phenoxybenzamine-d5 hydrochloride(Synonyms: 盐酸酚苄明 d5 (盐酸盐))

Phenoxybenzamine-d5 hydrochloride Chemical Structure

CAS No. : 1329838-45-0

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生物活性

Phenoxybenzamine-d5 hydrochloride is the deuterium labeled Phenoxybenzamine hydrochloride. Phenoxybenzamine hydrochloride is a selective antagonist of both α-adrenoceptor and calmodulin that is commonly used for the treatment of hypertension, specifically caused by pheochromocytoma.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

345.32

Formula

C18H18D5Cl2NO
CAS 号

1329838-45-0
中文名称

盐酸酚苄明 d5 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Lenox, R.H., et al, Alpha 2-adrenergic receptor-mediated regulation of adenylate cyclase in the intact human platelet. Evidence for a receptor reserve. Mol Pharmacol, 1985. 27(1): p. 1-9.

    [3]. Byon HJ, et al. Dexmedetomidine Inhibits Phenylephrine-induced Contractions via Alpha-1 Adrenoceptor Blockade and Nitric Oxide Release in Isolated Rat Aortae. Int J Med Sci. 2017 Feb 7;14(2):143-149.

    [4]. Lin XB, et al. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016 Mar;37(3):2901-8.

    [5]. Rau TF, et al. Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury. Int J Mol Sci. 2014 Jan 20;15(1):1402-17.

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