Rabeprazole-d4(Synonyms: LY307640-d4)

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Rabeprazole-d4 (Synonyms: LY307640-d4)

Rabeprazole D4 (LY307640 D4) 是 Rabeprazole 的一种氘代化合物。Rabeprazole 是一种二代质子泵抑制剂 (pump inhibitor, PPI)，不可逆地抑制胃 H+/K+-ATPase。Rabeprazole 诱导细胞凋亡 (apoptosis)。Rabeprazole 也抑制尿苷核苷核糖水解酶 (UNH) ，IC50 为 0.3 μM。Rabeprazole 可用于胃溃疡和胃食管反流的研究。

Rabeprazole-d4(Synonyms: LY307640-d4)

Rabeprazole-d4 Chemical Structure

CAS No. : 934295-48-4

规格 价格 是否有货
1 mg ￥2500 询问价格 & 货期
5 mg ￥9800 询问价格 & 货期

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生物活性

Rabeprazole D4 (LY307640 D4) is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

IC50 & Target

Pump inhibitor (PPI); UNH[1]
H+/K+-ATPase; Apoptosis[2]
分子量

363.47

Formula

C18H17D4N3O3S
CAS 号

934295-48-4
中文名称

雷贝拉唑 D4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tara A Shea, et al. Identification of Proton-Pump Inhibitor Drugs That Inhibit Trichomonas Vaginalis Uridine Nucleoside Ribohydrolase. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1080-4.

    [2]. Mengli Gu, et al. Rabeprazole Exhibits Antiproliferative Effects on Human Gastric Cancer Cell Lines. Oncol Lett. 2014 Oct;8(4):1739-1744.

    [3]. Aly A M Shaalan, et al. Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels. Front Pharmacol. 2020 May 13;11:583.

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