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Atiratecan (Synonyms: TP300)
Atiratecan (TP300) 是喜树碱类似物 CH0793076 (HY-107096) 的前药。Atiratecan 不抑制乙酰胆碱酯酶 (AChE) 活性。Atiratecan 在小鼠异种移植模型中显示出对乳腺癌抗性蛋白 (BCRP) 阳性和阴性异种移植物的抗肿瘤活性。
Atiratecan Chemical Structure
CAS No. : 867063-97-6
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生物活性 |
Atiratecan (TP300) is a prodrug of camptothecin analog CH0793076 (HY-107096). Atiratecan does not inhibit acetylcholinesterase (AChE) activities. Atiratecan shows antitumor activity against both breast cancer resistance protein (BCRP)-positive and -negative xenografts in mouse xenograft models[1]. |
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体外研究 (In Vitro) |
Atiratecan (TP300) is stable in an acidic solution but is rapidly converted to CH0793076 under physiological pH conditions such as in sera[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Atiratecan (TP300; 47 mg/kg; IV; once per week for 3 weeks) shows more than 50% of tumor growth inhibition in all nine models, regardless of the expression of BCRP[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
586.64 |
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Formula |
C31H34N6O6 |
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CAS 号 |
867063-97-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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