Clotrimazole-d5(Synonyms: 克霉唑 d5)

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Clotrimazole-d5 (Synonyms: 克霉唑 d5)

Clotrimazole-d5 是 Clotrimazole 的氘代物。Clotrimazole是咪唑衍生物，有抗真菌活性，是P450抑制剂。Clotrimazole 还具有抗菌活性。

Clotrimazole-d5(Synonyms: 克霉唑 d5)

Clotrimazole-d5 Chemical Structure

CAS No. : 1185076-41-8

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生物活性

Clotrimazole-d5 is the deuterium labeled Clotrimazole. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

349.87

Formula

C22H12D5ClN2
CAS 号

1185076-41-8
中文名称

克霉唑 d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Sawyer PR, Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1975;9(6):424-47.

    [3]. Witzke A, Inhibition of the gastric H,K-ATPase by clotrimazole. Biochemistry. 2010 Jun 1;49(21):4524-32.

    [4]. Schaller K. In vitro antibacterial activity of different clotrimazole formulations. Chemotherapy. 1982;28 Suppl 1:32-6.

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