N-Deshydroxyethyl Dasatinib-d8

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N-Deshydroxyethyl Dasatinib-d8 

N-Deshydroxyethyl Dasatinib-d8 是 N-Deshydroxyethyl Dasatinib 的氘代物。N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) 是一种基于 Dasatinib (ABL 抑制剂) 的配体，可通过 linker 与 IAP 配体结合从而形成 SNIPER 分子，从而降解 ABL。

N-Deshydroxyethyl Dasatinib-d8

N-Deshydroxyethyl Dasatinib-d8 Chemical Structure

CAS No. : 1189998-96-6

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生物活性

N-Deshydroxyethyl Dasatinib-d8 is the deuterium labeled N-Deshydroxyethyl Dasatinib. N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

452.00

Formula

C20H14D8ClN7OS
CAS 号

1189998-96-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

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