Alemtuzumab(Synonyms: Campath-IH; Lemtrada; MabCampath)

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Alemtuzumab (Synonyms: Campath-IH; Lemtrada; MabCampath)

Alemtuzumab (Campath-IH) 是一种抗 CD52 的人源化单克隆抗体,CD52 是一种糖蛋白,在大多数淋巴细胞表面表达,在较小程度上也表达于髓细胞类型。阿仑单抗选择性靶向 CD52 抗原,诱导淋巴细胞深度耗竭,然后恢复具有调节表型的 T 细胞和 B 细胞。

Alemtuzumab(Synonyms: Campath-IH;  Lemtrada;  MabCampath)

Alemtuzumab Chemical Structure

CAS No. : 216503-57-0

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生物活性

Alemtuzumab (Campath-IH) is a humanized monoclonal antibody against CD52, a glycoprotein expressed on the surface of most lymphoid, and to a lesser extent, myeloid cell types. Alemtuzumab selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes[1][2].

CAS 号

216503-57-0

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kashani N, et al. Immune Regulatory Cell Bias Following Alemtuzumab Treatment in Relapsing-Remitting Multiple Sclerosis. Front Immunol. 2021;12:706278. Published 2021 Oct 28.

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