MAO A/HDAC-IN-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

MAO A/HDAC-IN-1 

MAO A/HDAC-IN-1 是单胺氧化酶 A (MAO A) 和 HDAC 的双重抑制剂。MAO A/HDAC-IN-1 可用于胶质瘤研究。

MAO A/HDAC-IN-1

MAO A/HDAC-IN-1 Chemical Structure

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生物活性

MAO A/HDAC-IN-1 is a dual inhibitor of monoamine oxidase A (MAO A) and HDAC. MAO A/HDAC-IN-1 can be used for glioma research[1].

IC50 & Target[1]

MAO-A

 

体外研究
(In Vitro)

MAO A/HDAC-IN-1 (compound 15) increases histone H3 and α-tubulin acetylation and induce cell death via nonapoptotic mechanisms[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

MAO A/HDAC-IN-1 (compound 15) reduces tumor size, reduced MAO A activity in brain and tumor tissues, and prolonged the survival[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

401.89

Formula

C21H24ClN3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Samir Mehndiratta, et al. N-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment. J Med Chem. 2022 Feb 10;65(3):2208-2224.

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