DP-C-4

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

DP-C-4  纯度: 99.72%

DP-C-4 是一种基于 Cereblon 的双 PROTAC,用于同时降解 EGFRPARP

DP-C-4

DP-C-4 Chemical Structure

规格 价格 是否有货 数量
1 mg ¥2800 In-stock
5 mg ¥8500 In-stock
10 mg ¥13500 In-stock
50 mg   询价  
100 mg   询价  

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DP-C-4 相关产品

相关化合物库:

  • Bioactive Compound Library Plus

生物活性

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: SW1990 cells
Concentration: 1 μM, 3 μM, 5 μM, 10 μM, 30 μM, 50 μM
Incubation Time: 24 hours
Result: Had degradation effects on EGFR and PARP simultaneously in SW1990 cells.

分子量

1450.93

Formula

C72H78ClF2N15O14

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-80°C, stored under nitrogen

溶解性数据
In Vitro: 

DMSO : 12 mg/mL (8.27 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6892 mL 3.4461 mL 6.8921 mL
5 mM 0.1378 mL 0.6892 mL 1.3784 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months (stored under nitrogen)。-80°C 储存时,请在 6 个月内使用。

参考文献
  • [1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

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