cGMP-HTL(Synonyms: cGMP-HaloTag-ligand)

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cGMP-HTL (Synonyms: cGMP-HaloTag-ligand)

cGMP-HTL 包含一个HT 配体，一个linker 和自噬 tag Cys-S-cGMP。cGMP-HTL增加线粒体K63连接的泛素化。AUTAC(自噬靶向嵌合体)是一种新的靶向清除策略，它包含一个降解标签(鸟嘌呤衍生物)和一个“弹头”来提供靶向特异性。

cGMP-HTL(Synonyms: cGMP-HaloTag-ligand)

cGMP-HTL Chemical Structure

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生物活性

cGMP-HTL contains a HT-ligand, a linker and the Cys-S-cGMP (autophagy tag). cGMP-HTL increases the K63-linked ubiquitination of mitochondria. AUTAC (autophagy-targeting chimera) is a novel targeted-clearance strategy that contains a degradation tag (guanine derivatives) and a warhead to provide target specificity[1].

体外研究
(In Vitro)

cGMP-HTL (10 μM, 24 h) selective degrades S-guanylated EGFP[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HeLa cells expressing EGFP-HT protein.
Concentration: 10 μM.
Incubation Time: 0-24 h.
Result: Decrease in cGMP-modified EGFP and intact EGFP levels.

分子量

844.27

Formula

C31H51ClN7O14PS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.

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