Pomalidomide-amido-C3-piperazine-N-Boc

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Pomalidomide-amido-C3-piperazine-N-Boc 

Pomalidomide-amido-C3-piperazine-N-Boc 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Pomalidomide 的 cereblon 配体和 linker。可用于合成 PROTAC PD-1/PD-L1 degrader-1 (HY-131183)。

Pomalidomide-amido-C3-piperazine-N-Boc

Pomalidomide-amido-C3-piperazine-N-Boc Chemical Structure

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生物活性

Pomalidomide-amido-C3-piperazine-N-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].

IC50 & Target

Cereblon

 

分子量

555.58

Formula

C27H33N5O8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Binbin Cheng, et al. Discovery of Novel Resorcinol Diphenyl Ether-Based PROTAC-like Molecules as Dual Inhibitors and Degraders of PD-L1. Eur J Med Chem. 2020 Aug 1;199:112377.

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