STING agonist-3 trihydrochloride | 赛默飞Alfa aesar官网

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STING agonist-3 trihydrochloride

STING agonist-3 trihydrochloride 源于专利 WO2017175147A1 (实施例10)，是一种选择性和非核苷酸的小分子 STING 激动剂，pEC₅₀ 和 pIC₅₀ 分别为 7.5 和 9.5。STING agonist-3 trihydrochloride 具有持久的抗肿瘤作用，并且在改善癌症研究方面具有巨大潜力。

STING agonist-3 trihydrochloride Chemical Structure

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STING agonist-3 trihydrochloride 的其他形式现货产品:

STING agonist-3

生物活性	STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC₅₀ and pEC₅₀ of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer^[1].
IC₅₀ & Target	STING^[1]
体外研究 (In Vitro)	STING agonist-3 trihydrochloride exhibits a pEC₅₀ value of 7.5 in activation of STING in cells, this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter^[1]. STING agonist-3 trihydrochloride exhibits a pIC₅₀ value of 9.5 in FRET assay. This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	860.19
Formula	C₃₇H₄₅Cl₃N₁₂O₆
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Adam Kenneth, et al. Heterocyclic amides useful as protein modulators.patent WO2017175147A1

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