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PF-562271 hydrochloride (Synonyms: VS-6062(hydrochloride))
PF-562271 (VS-6062) hydrochloride 是一种有效,可逆,ATP 竞争性的 FAK 和 Pyk2 激酶抑制剂,IC50 分别为 1.5 nM 和 13 nM。
PF-562271 hydrochloride Chemical Structure
CAS No. : 939791-41-0
规格 | 是否有货 | ||
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100 mg | 询价 | ||
250 mg | 询价 | ||
500 mg | 询价 |
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PF-562271 hydrochloride 的其他形式现货产品:
生物活性 |
PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively[1]. |
IC50 & Target |
IC50: 1.5 nM (FAK), 13 nM (Pyk2), 30 nM (CDK2), 47 nM (CDK3), 58 nM (CDK1), 97 nM (CDK7), 97 nM (Flt3)[1] |
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体外研究 (In Vitro) |
PF-562271 (VS-6062) hydrochloride is shown to be a 30- to 120-nM inhibitor of CDK2/E, CDK5/p35, CDK1/B, and CDK3/E in recombinant enzyme assays, in cell-based assays evaluating the role of CDKs, a 48-hour exposure of 3.3 μM PF-562271 is required to alter cell cycle progression. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with a IC50 of 5 nM[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 (In Vivo) |
PF-562271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion (calculated EC50 of 93 ng/mL, total) after p.o. administration to tumor-bearing mice[1]. Rats that receive PF-562271 demonstrate a decrease in tumor growth after 2 weeks of treatment with signs of bone healing as evidenced by the deposition of new bone (cortical and cancellous) at sites previously damaged by the tumor[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
543.95 |
Formula |
C21H21ClF3N7O3S |
CAS 号 |
939791-41-0 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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