(S,R,S)-AHPC-C8-NH2 dihydrochloride(Synonyms: VH032-C8-NH2 dihydrochloride)

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(S,R,S)-AHPC-C8-NH2 dihydrochloride (Synonyms: VH032-C8-NH2 dihydrochloride)

(S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 VH032 的 VHL 配体和 1 个 linker。(S,R,S)-AHPC-C8-NH2 可用于合成靶向 AKT 的 PROTAC 降解剂,例 8,XF038-164A,源于专利文献 WO2019173516A1。

(S,R,S)-AHPC-C8-NH2 dihydrochloride(Synonyms: VH032-C8-NH2 dihydrochloride)

(S,R,S)-AHPC-C8-NH2 dihydrochloride Chemical Structure

CAS No. : 2341796-80-1

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(S,R,S)-AHPC-C8-NH2 dihydrochloride 的其他形式现货产品:

(S,R,S)-AHPC-C8-NH2

生物活性

(S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1[1].

IC50 & Target[1]

VHL

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

658.72

Formula

C31H49Cl2N5O4S

CAS 号

2341796-80-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. [1].Jian Jin, et al. Serine threonine kinase (akt) degradation / disruption compounds and methods of use. Patent WO2019173516A1.

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