(S,R,S)-AHPC-Me-C10-NH2

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(S,R,S)-AHPC-Me-C10-NH2 

(S,R,S)-AHPC-Me-C5-COOH 是一种合成的 E3 连接酶配体结合物,它结合了 VHL 配体和 linker。(S,R,S)-AHPC-Me-C5-COOH 可用于 PROTAC MS432 (HY-130602)。

(S,R,S)-AHPC-Me-C10-NH2

(S,R,S)-AHPC-Me-C10-NH2 Chemical Structure

CAS No. : 2376139-52-3

规格 价格 是否有货
50 mg ¥9600 询问价格 & 货期

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生物活性

(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602)[1].

IC50 & Target[1]

VHL

 

体外研究
(In Vitro)

MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

627.88

Formula

C34H53N5O4S

CAS 号

2376139-52-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献
  • [1]. Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019 Dec 12;62(23):10897-10911.

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