上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
TGFBR1-IN-1
TGFBR1-IN-1 是一种有效的选择性 ALK5 抑制剂，IC50 为 10-100 nM。详细信息请参考专利文献 WO2018004290A1 中的化合物 33。
TGFBR1-IN-1 Chemical Structure
CAS No. : 2170830-26-7
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| 生物活性 |
TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC50 of 10-100 nM[1]. |
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| IC50 & Target[1] |
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| 体外研究 (In Vitro) |
Transforming Growth Factor-β (TGF-β) signaling regulates various cellular responses such as cell proliferation, differentiation, cell migration and cell death. TGF-β has at least three isoforms TGF-β1, TGF-β2 and TGF-β3. TGF-β1 is two well-conserved single membrane serine/threonine kinase type I (ALK5). ALK5 inhibitos can be used for treating fibrotic disease, tumor, inflammatory disease, and autoimmune disease[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
427.48 |
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| Formula |
C23H17N5O2S |
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| CAS 号 |
2170830-26-7 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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