Aniline-MPB-amino-C3-PBD

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Aniline-MPB-amino-C3-PBD 

Aniline-MPB-amino-C3-PBD，是一种由吡咯苯二氮卓 (PBD) 组成的细胞毒性药物。Aniline-MPB-amino-C3-PBD 是一种序列选择性 DNA 小沟结合剂。Aniline-MPB-amino-C3-PBD 作为 ADC 的有效载荷。具有抗微生物活性。

Aniline-MPB-amino-C3-PBD

Aniline-MPB-amino-C3-PBD Chemical Structure

CAS No. : 2412923-79-4

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生物活性

Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

IC50 & Target

Pyrrolobenzodiazepines

 

体外研究
(In Vitro)

Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12 with potency of 2 pg/mL determined[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

758.86

Formula

C42H46N8O6
CAS 号

2412923-79-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. David Edwin Thurston, et al. Polycyclic amides as cytotoxic agents. WO2020049286A1.

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