(S,R,S)-AHPC-PEG2-NH2 dihydrochloride(Synonyms: VH032-PEG2-NH2 dihydrochloride)

发表于由

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(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (Synonyms: VH032-PEG2-NH2 dihydrochloride)

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-PEG2-NH2 dihydrochloride) 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker。可用于合成 PROTAC 分子。

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride(Synonyms: VH032-PEG2-NH2 dihydrochloride)

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride Chemical Structure

CAS No. : 2341796-76-5

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(S,R,S)-AHPC-PEG2-NH2 dihydrochloride 的其他形式现货产品:

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (S,R,S)-AHPC-PEG2-NH2

生物活性

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-PEG2-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1].

IC50 & Target

VHL

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

648.64

Formula

C28H43Cl2N5O6S
CAS 号

2341796-76-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.

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