Integrin-IN-2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Integrin-IN-2 

Integrin-IN-2 是口服生物利用泛 αv 整联蛋白 (αv integrin) 抑制剂。Integrin-IN-2 可以增加 αvβ6αvβ3αvβ5αvβ8 的结合亲和力,pIC50 值分别为 7.8、8.4、8.4 和 7.4。

Integrin-IN-2

Integrin-IN-2 Chemical Structure

CAS No. : 2378617-67-3

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生物活性

Integrin-IN-2 (compound 39) is an orally bioavailable pan αv integrin inhibitor. Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively[1].

IC50 & Target

pIC50: 7.8 (αvβ6), 8.4 (αvβ3), 8.4 (αvβ5) and 7.4 (αvβ8)[1]

体内研究
(In Vivo)

In vivo pharmacokinetic studies in CD rats revealed that racemic Integrin-IN-2 (compound 39) has a low plasma clearance of 8 mL/(min kg), a low to moderate volume of distribution of 0.5 L/kg, a moderate halflife of 1.8 h, and very high bioavailability of 98%[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

458.55

Formula

C27H30N4O3

CAS 号

2378617-67-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Anderson NA, et al. Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis. J Med Chem. 2019 Oct 10;62(19):8796-8808.

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