LMP744(Synonyms: MJ-III65; NSC706744)

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LMP744 (Synonyms: MJ-III65; NSC706744)

LMP744 (MJ-III65) 是一种 DNA 嵌合剂，是 拓扑异构酶 1 (Top1) 抑制剂，具有抗肿瘤活性。

LMP744(Synonyms: MJ-III65; NSC706744)

LMP744 Chemical Structure

CAS No. : 308246-52-8

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LMP744 的其他形式现货产品:

LMP744 hydrochloride

生物活性

LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].

IC50 & Target

Top1

 

体外研究
(In Vitro)

The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[2].
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: P388 and P388 Top1-deficient murine leukemia cells
Concentration: 0.1-100 μM
Incubation Time: 3 days
Result: Induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.

体内研究
(In Vivo)

LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1].
Dosage: 10, 25, or 50 mg/kg/week, 4 weeks
Administration: I.V. push via tail vein
Result: Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.

Clinical Trial

分子量

452.46

Formula

C24H24N2O7
CAS 号

308246-52-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30.

    [2]. Antony S, et al. Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Cancer Res. 2007 Nov 1;67(21):10397-405.

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