Datelliptium chloride

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Datelliptium chloride  纯度: 99.63%

Datelliptium chloride 是一种源于 ellipticine 的 DNA 嵌合剂,具有抗肿瘤活性。

Datelliptium chloride

Datelliptium chloride Chemical Structure

CAS No. : 105118-14-7

规格 价格 是否有货 数量
1 mg ¥10200 In-stock
5 mg ¥20300 In-stock
10 mg ¥34500 In-stock
20 mg ¥60900 In-stock
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Datelliptium chloride 相关产品

相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities.

体外研究
(In Vitro)

Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells[1]. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

397.94

Formula

C23H28ClN3O

CAS 号

105118-14-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 41.67 mg/mL (104.71 mM; Need ultrasonic)

DMSO : 5 mg/mL (12.56 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5129 mL 12.5647 mL 25.1294 mL
5 mM 0.5026 mL 2.5129 mL 5.0259 mL
10 mM 0.2513 mL 1.2565 mL 2.5129 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302.

    [2]. Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61.

Cell Assay
[1]

Cytotoxicity is estimated after short-term exposure (2 hr) to datelliptium using suspended and cultured rat hepatocytes. When cytotoxicity is evaluated after longer-term exposure, using human and rat monolayers and hepatoma cell lines, the compound is added 1 hr after cell plating and incubated for 23 hr. The loss of intracellular LDH and the MTT test are the endpoints evaluated in cultured cells. The intracellular LDH is measured in the microwell culture plates by a colorimetric method. The MTT test, reduction of the tetrazolium salt MTT to formazan by mitochondrial succinate dehydrogenase, is performed as described. Cytotoxicity in the hepatocyte suspension is evaluated by LDH leakage to the medium after a 2-hr treatment with the drug.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302.

    [2]. Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61.

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