上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
BML-111
BML-111 一种脂蛋白 A4 类似物,是一种脂蛋白 A4 (lipoxin A4) 受体激动剂。BML-111 可抑制血管紧张素转化酶 (ACE) 的活性,并增加血管紧张素转化酶 2 (ACE2) 的活性。BML-111 具有抗血管生成,抗肿瘤和抗炎的特性。
BML-111 Chemical Structure
CAS No. : 78606-80-1
规格 | 价格 | 是否有货 | |
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5 mg | ¥6800 | 询问价格 & 货期 |
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BML-111 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Immunology/Inflammation Compound Library
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Lipid Compound Library
- Anti-Cardiovascular Disease Compound Library
- Angiogenesis Related Compound Library
生物活性 |
BML-111, a lipoxin A4 analog, is a lipoxin A4 receptor agonist. BML-111 represses the activity of angiotensin converting enzyme (ACE) and increases the activity of angiotensinconverting enzyme 2 (ACE2). BML-111 has antiangiogenic, antitumor and anti-inflammatory properties[1][2]. |
IC50 & Target |
Lipoxin A4 receptor[1] |
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体外研究 (In Vitro) |
In H22 cells, BML-111 inhibits the production of vascular endothelial growth factor and reduces hypoxia-inducible factor-1α level[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
BML-111 (1 mg/kg; intraperitoneal injection; for 15 days; male Imprinting Control Region mice) treatment suppresses tumor-related angiogenesis and tumor growth in vivo. BML-111 also enhances the in situ apoptosis while inhibiting macrophage infiltration in tumor tissue[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
192.21 |
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Formula |
C8H16O5 |
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CAS 号 |
78606-80-1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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参考文献 |
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