Mc-Dexamethasone

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Mc-Dexamethasone 

Mc-Dexamethasone 是 ADC 的药物连接偶联物。Mc-Dexamethasone 将毒素地塞米松 (HY-14648) 偶联到不可裂解的 MC linker 上。Dexamethasone 是糖皮质激素受体激动剂。

Mc-Dexamethasone

Mc-Dexamethasone Chemical Structure

CAS No. : 1618096-56-2

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生物活性

Mc-Dexamethasone is a drug-linker conjugate for ADC. Mc-Dexamethasone is made toxin Dexamethasone (HY-14648) conjugated to the non-cleavable MC linker. Dexamethasone is a glucocorticoid receptor agonist[1].

IC50 & Target[1]

Maytansinoids

 

分子量

543.63

Formula

C29H38FN3O6
CAS 号

1618096-56-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

DMSO : 8.33 mg/mL (15.32 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8395 mL 9.1974 mL 18.3949 mL
5 mM 0.3679 mL 1.8395 mL 3.6790 mL
10 mM 0.1839 mL 0.9197 mL 1.8395 mL

参考文献

  • [1]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22.

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