TCO-PEG3-NHS ester

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TCO-PEG3-NHS ester 

TCO-PEG3-NHS ester 是一种 PROTAC linker，属于 PEG 类。TCO-PEG3-NHS ester 可用于合成一系列 PROTAC 分子。

TCO-PEG3-NHS ester

TCO-PEG3-NHS ester Chemical Structure

CAS No. : 2141981-88-4

规格 价格 是否有货
50 mg ￥9000 询问价格 & 货期

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生物活性

TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

470.51

Formula

C22H34N2O9
CAS 号

2141981-88-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (212.54 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1254 mL 10.6268 mL 21.2535 mL
5 mM 0.4251 mL 2.1254 mL 4.2507 mL
10 mM 0.2125 mL 1.0627 mL 2.1254 mL

参考文献

  • [1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.

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