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PhIP 纯度: 99.85%
PhIP 是在熟肉中形成的杂环芳香胺 (HAA),是一种可能的致癌物。具有 DNA 破坏性和诱变性。 PhIP 还具有雌激素活性,可能有助于其组织特异性致癌性。
PhIP Chemical Structure
CAS No. : 105650-23-5
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥5000 | In-stock | |
10 mg | ¥8500 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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PhIP 相关产品
•相关化合物库:
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- Anti-Cancer Compound Library
- Clinical Compound Library
- Anti-Aging Compound Library
- Oxygen Sensing Compound Library
- Anti-Breast Cancer Compound Library
- Tumorigenesis Related Compound Library
生物活性 |
PhIP is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat[1][2]. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity[2]. |
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体外研究 (In Vitro) |
PhIP causes widespread and largely over-lapping effects on miRNA expression. PhIP induces widespread effects via activation of oestrogen receptor alpha (ERα). Deregulation of miRNA by PhIP could potentially be an important non-DNA-damaging carcinogenic mechanism in breast cancer[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
In hCYP1A-mice, PhIP induces inflammation, epithelial cell damage, and prostatic intraepithelial neoplasia in the dorsolateral prostate lobe compared to the ventral lobe. PhIP forms DNA adducts in the prostate, PhIP also induces oxidative stress, atrophy of the acini, and inflammation of the prostate of rodents[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
224.26 |
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Formula |
C13H12N4 |
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CAS 号 |
105650-23-5 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 25 mg/mL (111.48 mM; ultrasonic and warming and heat to 60°C) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
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参考文献 |
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