HMN-154

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HMN-154  纯度: 97.18%

HMN-154是一种新型的苯磺酰胺类抗癌化合物。HMN-154与NF-YB相互作用，从而中断NF-Y异源三聚体与DNA的结合。

HMN-154

HMN-154 Chemical Structure

CAS No. : 173528-92-2

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2338 In-stock
5 mg ￥2900 In-stock
10 mg ￥4400 In-stock
25 mg ￥6500 In-stock
50 mg ￥8000 In-stock
100 mg ￥9500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

HMN-154 相关产品

•相关化合物库:

  • Natural Product Like Compound Library
  • Natural Product Like Compound Library
  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library

生物活性

HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively.

IC50 & Target

IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells)[1]
体外研究
(In Vitro)

HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

366.43

Formula

C20H18N2O3S
CAS 号

173528-92-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 15 mg/mL (40.94 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7290 mL 13.6452 mL 27.2903 mL
5 mM 0.5458 mL 2.7290 mL 5.4581 mL
10 mM 0.2729 mL 1.3645 mL 2.7290 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Tanaka H, et al. Isolation of cDNAs encoding cellular drug-binding proteins using a novel expression cloning procedure: drug-western. Mol Pharmacol. 1999 Feb;55(2):356-63.
Cell Assay
[1]

Cells are seeded into a 96-well microplate at a cell density of 10000/well. Drug is added on the next day, and the plate then is incubated for 72 h at 37°C. The growth inhibitory concentration is measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Tanaka H, et al. Isolation of cDNAs encoding cellular drug-binding proteins using a novel expression cloning procedure: drug-western. Mol Pharmacol. 1999 Feb;55(2):356-63.

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