2’-Oxo Ifosfamide-d4(Synonyms: 异环磷酰胺 d4)

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2’-Oxo Ifosfamide-d4 (Synonyms: 异环磷酰胺 d4)

2’-Oxo Ifosfamide-d4 是 Ifosfamide 的氘代物。Ifosfamide 是一种烷化剂 (DNA alkylator)，具有广谱的抗肿瘤作用。

2’-Oxo Ifosfamide-d4(Synonyms: 异环磷酰胺 d4)

2’-Oxo Ifosfamide-d4 Chemical Structure

CAS No. : 1329497-14-4

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生物活性

2’-Oxo Ifosfamide-d4 is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

279.09

Formula

C7H9D4Cl2N2O3P
CAS 号

1329497-14-4
中文名称

异环磷酰胺 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Helal M. Prenatal effects of transplacental exposure to ifosfamide in rats. Biotech Histochem. 2016 Jul;91(5):357-68.

    [3]. Karle P, et al. Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001 Mar;8(3):220-30.

    [4]. Vredenburg G, et al. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicol Lett. 2015 Jan 5;232(1):182-92.

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