JMS-17-2 hydrochloride

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

JMS-17-2 hydrochloride 

JMS-17-2 hydrochloride 是一种有效的选择性 CX3CR1 拮抗剂，IC50 为 0.32 nM。JMS-17-2 hydrochloride 降低乳腺癌细胞的转移和定植。

JMS-17-2 hydrochloride

JMS-17-2 hydrochloride Chemical Structure

CAS No. : 2341841-07-2

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JMS-17-2 hydrochloride 的其他形式现货产品:

JMS-17-2

生物活性

JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells[1].

IC50 & Target

IC50: 0.32 nM (CX3CR1)[1]
体内研究
(In Vivo)

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice (~25g) with MDA-231 xenograft[1]
Dosage: 10 mg/kg
Administration: Aministered i.p.; twice a day for three weeks
Result: Caused a dramatic reduction of tumors in both skeleton and visceral organs.

分子量

456.41

Formula

C25H27Cl2N3O
CAS 号

2341841-07-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27.

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