Amlodipine-1,1,2,2-d4 maleate(Synonyms: 氨氯地平 d4 (马来酸盐))

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Amlodipine-1,1,2,2-d4 maleate (Synonyms: 氨氯地平 d4 (马来酸盐))

Amlodipine-1,1,2,2-d4 maleate 是 Amlodipine 的氘代物。Amlodipine 是一种抗心绞痛药和具有口服活性二氢吡啶钙通道阻滞剂，通过阻断电压依赖性的 L 型钙通道，从而抑制钙离子内流。Amlodipine 可用于高血压和癌症的研究。

Amlodipine-1,1,2,2-d4 maleate(Synonyms: 氨氯地平 d4 (马来酸盐))

Amlodipine-1,1,2,2-d4 maleate Chemical Structure

CAS No. : 1185246-15-4

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生物活性

Amlodipine-1,1,2,2-d4 maleate is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

528.97

Formula

C24H25D4ClN2O9
CAS 号

1185246-15-4
中文名称

氨氯地平 d4 (马来酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Kishen G. Bulsara, et al. Amlodipine.

    [3]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586.

    [4]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12.

    [5]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87.

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