AC-386

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

AC-386 

AC-386 是一种高效的 c-Met 抑制剂，IC50 为 7.42 nM。AC-386 对几种癌细胞具有抗增殖活性。AC-386 可用于抗癌耐药研究。

AC-386

AC-386 Chemical Structure

CAS No. : 1902910-89-7

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生物活性

AC-386 is a highly potent c-Met inhibitor with IC50 value of 7.42 nM. AC-386 has antiproliferative activities against certain cancer cell lines. AC-386 can be used for researching anti-cancer resistance[1].

IC50 & Target[1]

c-Met

7.42 nM (IC50)

体外研究
(In Vitro)

AC-386 (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: HCT-116, MCF-7 and A549[1]
Concentration: 0-20 μM
Incubation Time: 72 hours
Result: Exhibited antiproliferative activities against HCT-116, MCF-7 and A549 with IC50s of 0.37 ± 0.02 μM, 0.63 ± 0.05 μM, 1.12 ± 0.10 μM in HCT-116, MCF-7 and A549, respectively.

分子量

639.67

Formula

C35H34FN5O6
CAS 号

1902910-89-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hu H, Chen F, Dong Y, et al. Discovery of Novel c-Mesenchymal-Epithelia transition factor and histone deacetylase dual inhibitors. Eur J Med Chem. 2020;204:112651.

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