Azido-PEG2-VHL

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Azido-PEG2-VHL 

Azido-PEG2-VHL 是一种多激酶降解剂,可用于 PROTAC 的合成。

Azido-PEG2-VHL

Azido-PEG2-VHL Chemical Structure

CAS No. : 2597167-22-9

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生物活性

Azido-PEG2-VHL is a multikinase degrader which can be used in the synthesis of PROTACs[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

615.74

Formula

C29H41N7O6S

CAS 号

2597167-22-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. STATSYUK A, et, al. Multikinase degraders. WO2021021797A1.

    [2]. Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.

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